LOCAMETZ Dosing & Administration
Radiation Safety
LOCAMETZ IS AVAILABLE AS A KIT FOR THE PREPARATION OF GALLIUM Ga 68 GOZETOTIDE SOLUTION FOR INJECTION1
Radiopharmaceuticals should be used by or under the control of health care providers (HCPs) who are qualified by specific training and experience in the safe use and handling of radionuclides, and whose experience and training have been approved by the governmental agency authorized to license the use of radionuclides.
 | Use waterproof gloves, effective radiation shielding, and other appropriate safety measures when preparing and handling gallium Ga 68 gozetotide solution |
| After reconstitution, handle the gallium Ga 68 gozetotide solution for injection with appropriate safety measures in order to avoid radiation exposure to occupational workers, clinical personnel, and other persons |
LOCAMETZ can be prepared and labeled at the hospital radiopharmacy and used onsite or delivered to the hospital ready to inject.
Learn about the 3-step radiolabeling process
Dosing and Administration
PROCESS FOR PREPARING THE PATIENT, VERIFYING THE DOSE, AND PROPER DISPOSAL1
The recommended amount of radioactivity to be administered for PET is 111 MBq (3 mCi) up to a maximum of 259 MBq (7 mCi). Administered as a slow intravenous injection.
MBq, megabecquerel; mCi, millicurie; PET, positron emission tomography.
 | Prior to use, visually inspect the prepared gallium Ga 68 gozetotide solution for injection behind a lead-glass shield for radioprotection purposes. Use only solutions that are clear, colorless, and free from particulate matter |
 | After radiolabeling, gallium Ga 68 gozetotide injection may be diluted with sterile water for injection, USP, or 0.9% sodium chloride injection, USP, up to a final volume of 10 mL |
 | Advise patients to be well hydrated prior to administration and to void immediately prior to and frequently after image acquisition to reduce radiation exposure |
USP, US Pharmacopeia.
Storage and Handling
LOCAMETZ CAN BE STORED AT CONTROLLED ROOM TEMPERATURE1
 | |
Before reconstitution Store between 36°F and 77°F Do not freeze | After radiolabeling Store upright, below 86°F Do not freeze |
After radiolabeling, gallium Ga 68 gozetotide solution for injection must be used within 4 hours | |
HANDLING LOCAMETZ REQUIRES APPROPRIATE SAFETY MEASURES FOR MINIMIZING RADIATION EXPOSURE1,2
LOCAMETZ should be administered only under the control of trained/licensed HCPs
Use waterproof gloves
Use effective radiation shielding
Minimize handling time
Any unused product or waste material should be disposed of in accordance with local and federal laws
Receipt, transfer, handling, possession, or use of LOCAMETZ is subject to radioactive material regulations and licensing requirements. Please check with your institution’s radiation safety department and team for any further institution-specific requirements that should be followed for the administration of LOCAMETZ.
Resources
RADIOLABELING LOCAMETZ
For the Eckert & Ziegler GalliaPharm® Generator
Watch this video to learn about the 3-step radiolabeling process for LOCAMETZ using the Eckert & Ziegler GalliaPharm® generator
For the IRE ELiT Galli Eo™ Generator
Watch this video to learn about the 3-step radiolabeling process for LOCAMETZ using the IRE ELiT Galli Eo™ generator