About PSMA PET/CT Imaging in Prostate Cancer

About PSMA PET/CT Imaging

Characteristics of PSMA

PSMA IS A BIOMARKER IN PROSTATE CANCER^1-4

What makes PSMA an ideal target for imaging and treatment?

PSMA CHARACTERISTIC		WHAT IT MEANS
	PSMA is overexpressed on prostate cancer (PC) cells in >80% of men with PC^5-9	Serves as an actionable biomarker, providing an accessible target for ligand binding^5-9
	Ligands are internalized after binding with PSMA and undergo endocytic recycling^2,3	Facilitates uptake of gallium 68 in PSMA+ cells, including tumor cells^2,3
	PSMA is not appreciably released into circulation, even in patients with progressive disease¹⁰	Facilitates highly specific targeting of PSMA+ lesions¹⁰

CT, computed tomography; PET, positron emission tomography; PSMA, prostate-specific membrane antigen; PSMA+, PSMA positive.

PSMA PET Imaging in Prostate Cancer

GALLIUM Ga 68 GOZETOTIDE PSMA PET IMAGING HAS BEEN STUDIED IN MULTIPLE TRIALS AND IS APPROVED FOR PATIENTS WITH PROSTATE CANCER^11-14

For selection of patients with metastatic prostate cancer for whom lutetium Lu 177 vipivotide tetraxetan PSMA-directed therapy is indicated¹⁵
For patients with suspected metastasis who are candidates for initial definitive therapy¹⁵
For patients with suspected recurrence based on elevated serum prostate-specific antigen (PSA) level¹⁵

If you're considering a PSMA PET/CT scan for your patient, find a LOCAMETZ Scanning Center near you

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